Alzheimer’s Disease

Anti-inflammatory, antioxidant, antiapoptotic; in vitro and in vivo models of Aβ-evoked neuroinflammatory and neurodegenerative responses.

Anxiety

Reduction of muscular tension, restlessness, fatigue, problems in concentration, improvement of social interactions in rodent models of anxiety, and stress; reduced social anxiety in patients.

Cancer

Antiproliferative and anti-invasive actions in a large range of cancer types; induction of autophagy-mediated cancer cell death; chemo-preventive effects.

Cardiovascular Diseases

Reduced infarct size through anti-oxidant and anti-inflammatory properties in vitro and in vivo.

Depression

Anti-depressant effect in a genetic rodent model of depression.

Diabetic Complications

Attenuation of fibrosis and myocardial dysfunction.

Huntington’s Disease

Neuroprotective and antioxidant in mice transgenic models; no significant clinically important differences in patients.

Hypoxia-ischemia Injury

Short term neuroprotective effects; inhibition of excitotoxicity, oxidative stress and inflammation in vitro and in rodent models.

Infection Activity against methicillin-resistant Staphylococcus aureus.

Inflammatory Bowel and Crohn’s Diseases

Inhibition of macrophage recruitment and TNF-α secretion in vivo and ex vivo; reduction in disease activity index in Crohn’s patients.

Inflammatory Diseases

Anti-inflammatory properties in several in vitro and in vivo models; inhibition of inflammatory cytokines and pathways.

Multiple Sclerosis

Improved signs of EAE in mice, anti-inflammatory and immunomodulatory properties.

Nausea 

Suppression of nausea and conditioned gaping in rats.

Pain

Analgesic effect in patients with neuropathic pain resistant to other treatments.

Parkinson’s Disease

Attenuation of the dopaminergic impairment in vivo; neuro-protection; improvement of psychiatric rating and reduction of agitation, nightmare and aggressive behavior in patients.

Psychosis

Attenuation of the behavioral and glial changes in animal models of schizophrenia; anti-psychotic properties on ketamine-induced symptoms.

Rheumatoid Arthritis

Inhibition of TNF-α in an animal model.